Rubidium-82 myocardial uptake and extraction after transient ischemia: PET characteristics

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Comput. Assist. Tomogr.; (United States)

DOI:https://doi.org/10.1097/00004728-198701000-00012· OSTI ID:6702616

Wilson, R A; Shea, M; Landsheere, C D; Deanfield, J; Lammertsma, A A; Jones, T; Selwyn, A P

The effects of transient regional ischemia on monovalent cation uptake and extraction by the myocardium were studied in seven open chest dogs. Following a 10-20% stenosis of the left anterior descending coronary artery to prevent reactive hyperemia, the regional myocardial uptake of the monovalent cation /sup 82/Rb (ml/min/g X extraction) was measured before, during, and at 10, 30, and 60-80 min after a 10 min total occlusion of the left anterior descending coronary artery using positron emission tomography. Regional myocardial blood flow was also measured at the same time interval using radiolabeled carbonized microspheres. The regional myocardial extraction of /sup 82/Rb was calculated as uptake/flow. In normally perfused myocardial regions there was an inverse relationship between /sup 82/Rb extraction and blood flow (extraction = -0.56 (In flow) + 0.46, r = 0.93) over a range of flow from 0.3 to 4 ml/min/g. During the prolonged recovery of /sup 82/Rb uptake in the transiently ischemic region, flow had returned to normal levels but /sup 82/Rb extraction at a given value of flow was significantly decreased at the 30 and 60-80 min times after release of the occlusion compared with normally perfused regions. Thus, prolonged abnormalities in the /sup 82/Rb uptake and extraction occur in myocardium recovering from transient ischemia.

• Research Organization: Royal Postgraduate Medical School, London, England
• OSTI ID: 6702616
• Journal Information: J. Comput. Assist. Tomogr.; (United States), Journal Name: J. Comput. Assist. Tomogr.; (United States) Vol. 1; ISSN JCATD
• Country of Publication: United States
• Language: English

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