Applications of scanning electron microscopy and X-ray microanalysis in inner ear pathology
Surface pathology of inner ear structures so far described in detail concern cochlear and vestibular hair cells and the stria vascularis. In man, surgical intervention into the inner ear is very uncommon and when performed is in general with the primary objective of destroying the diseased peripheral end organs. The vast majority of inner ear tissue available for use with scanning electron microscopy (SEM) is therefore obtained from animals. The present paper reviews the progression of surface pathology caused by aminoglycoside antibiotics, acoustic overstimulation and in a guinea pig strain with genetic inner ear disease. The primary site of onset of surface pathology differs, depending on the underlying cause. Advanced surface pathology shows a similar type of morphological degeneration independent of cause. The combination of SEM and energy dispersive X-ray microanalysis (XRMA) of inner ear pathology has as yet been reported in only three studies, all concerning inner ear fluids or otoconia.
- OSTI ID:
- 5028080
- Journal Information:
- Scanning Electron Microsc.; (United States), Journal Name: Scanning Electron Microsc.; (United States) Vol. 1; ISSN SEMYB
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BODY
CHEMICAL ANALYSIS
DISEASES
DRUGS
ELECTRON MICROPROBE ANALYSIS
ELECTRON MICROSCOPY
GUINEA PIGS
HEREDITARY DISEASES
INJURIES
MAMMALS
MICROANALYSIS
MICROSCOPY
NOISE
ORGANS
PATHOLOGY
RODENTS
SCANNING ELECTRON MICROSCOPY
SENSE ORGANS
VERTEBRATES