Mechanism of the formation of x-ray-induced phosphenes. II. Photochemical investigations
Journal Article
·
· Radiat. Res.; (United States)
Like visible light, x rays can stimulate the isolated retina and induce an action potential (ERG). To explain the modalities of interaction of incident radiation with the photoreceptor cells, we studied the modifications of the rhodopsin absorption spectrum after x irradiation. For exposures smaller than 5 x 10/sup 5/ R, a large increase in absorption in the uv part of the spectrum is observed. For exposure of 1.25 x 10/sup 6/ R, a 20% decrease is measured in the characteristic peak of rhodopsin (500 nm). In comparison to what is known for visible light, the significant bleaching of rhodopsin by x rays can account for the initiation of an ERG in the isolated retina. By analogy with the enzymatic inactivation after x irradiation, we believe that the x-ray rhodopsin bleaching could be due to an energy transfer from the opsin to the attachment site of the chromophoric group (11-cis retinal). The disorganization of this critical site of the molecule could be at the origin of the rod excitation, then of the ERG.
- Research Organization:
- Laboratoire de Biophysique, Clermont-Ferrand, France
- OSTI ID:
- 5025837
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
551000 -- Physiological Systems
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
BODY AREAS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
COMPARATIVE EVALUATIONS
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DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
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HEAD
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IONIZING RADIATIONS
KINETICS
MAMMALS
NUMERICAL DATA
ORGANS
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RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
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RETINA
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551000 -- Physiological Systems
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
BODY AREAS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
COMPARATIVE EVALUATIONS
DATA
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EYES
FACE
FUNCTIONS
HEAD
INFORMATION
IONIZING RADIATIONS
KINETICS
MAMMALS
NUMERICAL DATA
ORGANS
PIGMENTS
RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RATS
REACTION KINETICS
RETINA
RODENTS
SENSE ORGANS
SPECTRA
SPECTRAL FUNCTIONS
VERTEBRATES
VISIBLE RADIATION
X RADIATION