Quantitative evaluation of L-(methyl-C-11) methionine uptake in tumor using positron emission tomography

Journal Article · Tue Oct 31 23:00:00 EST 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5024932

Hatazawa, J; Ishiwata, K; Itoh, M; Kameyama, M; Kubota, K; Ido, T; Matsuzawa, T; Yoshimoto, T; Watanuki, S; Seo, S ^[1]

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1. Tohoku Univ. (Japan)

Tumor uptake of L-(methyl-{sup 11}C)methionine (({sup 11}C)Met) was assessed in six patients with brain tumors and three patients with lung cancer using positron emission tomography (PET). In arterial plasma samples taken at 5, 15, 30, and 60 min after injection, a fraction of ({sup 11}C)Met was measured using high performance liquid chromatography in individual patients. Employing curve fitting, a history of ({sup 11}C)Met activity was obtained as an input function. By means of sequential PET scannings and graphic analysis, uptake rate and distribution volume of ({sup 11}C)Met in tumor tissue were calculated. In two studies irreversible uptake into the tumors was not seen when total plasma {sup 11}C activity was used as the input; however when ({sup 11}C)Met plasma activity was used, definite irreversible uptake was seen, indicating tumor viability. In other studies, up to 24% underestimation of uptake rate was found. The present results demonstrated the importance of measuring ({sup 11}C)Met in plasma for quantitative assessment of in vivo amino acid metabolism in tumors.

• OSTI ID: 5024932
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 30:11; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
CLEARANCE
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPOTROPIC FACTORS
LIQUID COLUMN CHROMATOGRAPHY
LUNGS
METHIONINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
SEPARATION PROCESSES
TOMOGRAPHY
UPTAKE