Formaldehyde: An experimental multipotential carcinogen

Journal Article · Sun Oct 01 04:00:00 EDT 1989 · Toxicology and Industrial Health; (USA)

DOI:https://doi.org/10.1177/074823378900500510· OSTI ID:5024416

Soffritti, M; Maltoni, C; Maffei, F; Biagi, R ^[1]

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1. Institute of Oncology F. Addarii, Bologna (Italy)

Male and female Sprague-Dawley rats of different ages at the start of the experiments (12 day embryos, and 7 and 25 weeks old) were administered fromaldehyde in drinking water at different doses (2,500 or 1,500, 1,000, 500, 100, 50, 10, 0 ppm). An increased incidence of leukemias and of gastro-intestinal tumors was observed in formaldehyde treated rats. Gastro-intestinal tumors are exceptionally rare in the rats of the colony used. These results, together with the ones obtained by other authors on rats exposed by inhalation to formaldehyde, indicate that this compound is an experimental multipotential carcinogen. The experimental results presented in this report give scientific support to the epidemiological observation of a higher incidence of leukemias and of gastro-intestinal cancers among the people occupationally exposed.

• OSTI ID: 5024416
• Journal Information: Toxicology and Industrial Health; (USA), Journal Name: Toxicology and Industrial Health; (USA) Vol. 5:5; ISSN TIHEE; ISSN 0748-2337
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
CARCINOGENESIS
DIGESTIVE SYSTEM
DISEASES
FORMALDEHYDE
GASTROINTESTINAL TRACT
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
INHALATION
INTAKE
LEUKEMIA
MAMMALS
MAN
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
PRIMATES
RATS
RODENTS
VERTEBRATES