Quinine-induced thrombocytopenia following intravenous use of heroin
Profound thrombocytopenia developed in a 22-year-old man after intravenous use of heroin. A high-titer, quinine-dependent, platelet-specific antibody was detected in his serum using lysis of normal platelets labeled with chromium 51 and an electroimmunoassay for measurement of platelet-associated IgG. The antibody was specific for quinine and failed to react with platelets in the presence of quinidine hydrochloride or two structural analogues of heroin. Quinine, a common adulterant found in heroin, was detected in the patient's blood and urine. On the basis of these observations, the patient was judged to have quinine-induced immunologic thrombocytopenia. To our knowledge, this report is the first to confirm that quinine used as an adulterant can induce immunologic thrombocytopenia following an injection of heroin.
- Research Organization:
- Blood Center of Southeastern Wisconsin, Inc., Milwaukee
- OSTI ID:
- 5024131
- Journal Information:
- Arch. Intern. Med.; (United States), Vol. 143:6
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
HEMIC DISEASES
DIAGNOSIS
HEROIN
BIOLOGICAL EFFECTS
ANTIBODY FORMATION
BLOOD PLATELETS
CHROMIUM 51
IMMUNOGLOBULINS
QUININE
RADIOIMMUNOASSAY
ALKALOIDS
ANALGESICS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHROMIUM ISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBULINS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MORPHINE
NARCOTICS
NUCLEI
OPIUM
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOISOTOPES
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550301 - Cytology- Tracer Techniques