Quinine-induced thrombocytopenia following intravenous use of heroin
Profound thrombocytopenia developed in a 22-year-old man after intravenous use of heroin. A high-titer, quinine-dependent, platelet-specific antibody was detected in his serum using lysis of normal platelets labeled with chromium 51 and an electroimmunoassay for measurement of platelet-associated IgG. The antibody was specific for quinine and failed to react with platelets in the presence of quinidine hydrochloride or two structural analogues of heroin. Quinine, a common adulterant found in heroin, was detected in the patient's blood and urine. On the basis of these observations, the patient was judged to have quinine-induced immunologic thrombocytopenia. To our knowledge, this report is the first to confirm that quinine used as an adulterant can induce immunologic thrombocytopenia following an injection of heroin.
- Research Organization:
- Blood Center of Southeastern Wisconsin, Inc., Milwaukee
- OSTI ID:
- 5024131
- Journal Information:
- Arch. Intern. Med.; (United States), Journal Name: Arch. Intern. Med.; (United States) Vol. 143:6; ISSN AIMDA
- Country of Publication:
- United States
- Language:
- English
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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALOIDS
ANALGESICS
ANTI-INFECTIVE AGENTS
ANTIBODY FORMATION
ANTIMICROBIAL AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHROMIUM 51
CHROMIUM ISOTOPES
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBULINS
HEMIC DISEASES
HEROIN
IMMUNOGLOBULINS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MORPHINE
NARCOTICS
NUCLEI
OPIUM
ORGANIC COMPOUNDS
PROTEINS
QUININE
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
TRACER TECHNIQUES