Neonatal developmental pattern of superoxide dismutase and aniline hydroxylase in rat lung
The developmental biology of superoxide dismutase and aniline hydroxylase was followed in rat lungs from prenatal stage to 3 months old. Total superoxide dismutase activity as determined by spectrophotometry as well as electrophoresis was high in the prenatal rat lung, decreased in the first 24 hr postpartum, increased within 7 days, and then decreased gradually to adult levels. On polyacrylamide gel electrophoresis only two isozymic forms of superoxide dismutase were located as achromatic zones in the fetal lung. In the adult rat lung, there were three molecular forms of superoxide dismutase, two in the postmitochondrial supernatant and one in the mitochondrial fraction. Unlike superoxide dismutase, aniline hydroxylase was detectable only after 5 days of age and the activity exhibited a gradual increase afterward up to 1 month of age. The developmental pattern of superoxide dismutase and aniline hydroxylase activities in lung may be significant in understanding the mechanism of body defenses and their regulatory modulations in response to toxic air pollutants and environmental stress.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow, India
- OSTI ID:
- 5023541
- Journal Information:
- Environ. Res.; (United States), Vol. 41:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENZYME ACTIVITY
ONTOGENESIS
HYDROXYLASES
LUNGS
SUPEROXIDE DISMUTASE
AGE DEPENDENCE
AIR POLLUTION
EXPERIMENTAL DATA
IMMUNITY
NEONATES
POLLUTANTS
RATS
ANIMALS
BODY
DATA
ENZYMES
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANS
OXIDOREDUCTASES
POLLUTION
RESPIRATORY SYSTEM
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VERTEBRATES
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