Structure of phospholipid monolayers containing poly(ethylene glycol) lipids at the air-water interface
Journal Article
·
· Journal of Physical Chemistry B: Materials, Surfaces, Interfaces, amp Biophysical
- Los Alamos National Lab., NM (United States)
- Univ. of California, Santa Barbara, CA (United States)
- Riso National Univ., Roskilde (Denmark)
The density distribution of a lipid monolayer at the air-water interface mixed with varying amounts of lipid with poly(ethylene glycol)polymer headgroups (polymer-lipid or PEG-lipid) was measured using neutron reflectometry. The structure of the monolayer at the interface was greatly perturbed by the presence of the bulky polymer-lipid headgroups resulting in a large increase in the thickness of the headgroup region normal to the interface and a systematic roughening of the interface with increasing polymer-lipid content. These results show how bulky hydrophilic moieties cause significant deformations and out-of-place protrusions of phospholipid monolayers and presumably bilayers, vesicles and biological membranes. In terms of polymer physics, very short polymer chains tethered to the air-water interface follow scaling behavior with a mushroom to brush transition with increasing polymer grafting density. 34 refs., 9 figs., 1 tab.
- DOE Contract Number:
- FG03-87ER45331; W-7405-ENG-36
- OSTI ID:
- 501941
- Journal Information:
- Journal of Physical Chemistry B: Materials, Surfaces, Interfaces, amp Biophysical, Journal Name: Journal of Physical Chemistry B: Materials, Surfaces, Interfaces, amp Biophysical Journal Issue: 16 Vol. 101; ISSN 1089-5647; ISSN JPCBFK
- Country of Publication:
- United States
- Language:
- English
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