Characterization of a new HLA-B allele (B{sup *}3702) generated by an intronic recombination event
- Regional Transfusion Centre, Madrid (Spain)
Routine serological HLA typing of s Syrian family revealed a Bw4-associated HLA-B blank antigen showing Mendelian segregation together with the haplotype A1, Cw2, DR11, DQ7 (a father and one of his children, cells NO. 5958641 and No. 1958125). A more extensive serological analysis was done by using additional polyclonal and monoclonal antibodies (mAb; One-Lambda BL-60 and LM172 plates) as well as the 12th International Workshop class I mAb plate. Both cells showed no conclusive typing reactions with sera towards HLA-B27 and HLA-B37 antigens. Two mAb, PAMELA (27,44,38) and FAY (13,27,37,47), were able to recognize this antigen. The great majority of polyclonal reagents against B37 showed negative reactions, while weak results were frequently observed with anti-B27 allosera. 8 refs., 1 fig., 1 tab.
- OSTI ID:
- 501877
- Journal Information:
- Immunogenetics, Vol. 43, Issue 3; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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