Mouse HLA-DPA homologue H2-Pa: A pseudogene that maps between H2-Pb and H2-Oa
- Hokkaido Univ., Sapporo (Japan)
The major histocompatibility complex (MHC) class II subregion contains several subclasses of genes. The classical class II genes, HLA-DP, DQ, and DR homologues, present antigens directly to CD4{sup +} T cells. HLA-DM homologues facilitate the efficacy and transport of antigens to the cell surface by removing the CLIP peptides from the classical class II molecules. HLA-DNA/DOB homologues show unusual expression patterns and limited polymorphism, but their function is yet to be elucidated. 15 refs., 2 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 501871
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 3 Vol. 43; ISSN 0093-7711; ISSN IMNGBK
- Country of Publication:
- United States
- Language:
- English
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