Postprandial hemodynamics in the conscious rat
The postprandial intestinal hyperemia was studied in conscious and anesthetized rats using the radioactive microsphere technique. Carbohydrate, protein, lipid, and mixed meals, and the vehicle (Tyrode's solution), were placed in the stomach via a gastrostomy tube. In conscious rats, blood flow increased by 40-80% in the duodenum and jejunum 1 h after either a carbohydrate, lipid, protein, or mixed meal. Tyrode's solution produced a comparable hyperemia. Blood flow in the distal bowel segments (ileum, cecum, and colon) was significantly increased only by Tyrode's solution and the carbohydrate meal. The proximal intestinal hyperemia produced by the mixed meal in conscious animals was significantly attenuated by vagotomy yet unaltered by atropine pretreatment. In contrast to the results obtained from conscious rats, the mixed meal did not significantly alter intestinal blood flow in anesthetized animals. The results of this study indicate that the postprandial intestinal hyperemia is much greater in conscious than anesthetized animals. This difference may result from the higher resting blood flows in the latter group. The hyperemic response in conscious animals may be mediated by the vagus nerve.
- OSTI ID:
- 5017360
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States); ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ALKALOIDS
ANIMALS
ATROPINE
AUTONOMIC NERVOUS SYSTEM AGENTS
BLOOD FLOW
BODY
DIGESTION
DIGESTIVE SYSTEM
DRUGS
FOOD
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPE APPLICATIONS
MAMMALS
MICROSPHERES
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOLYTICS
PHYSIOLOGY
RATS
RODENTS
STOMACH
TRACER TECHNIQUES
VERTEBRATES