Cyclic, low-dose total body irradiation for metastatic neuroblastoma
Total body irradiation (TBI) can be thought of as a systemic anticancer agent. It therefore might best be given like an adjuvant drug, i.e., in tolerable doses, cyclically. The therapeutic ratio between normal bone marrow stem cells and suitably sensitive cancer cells should be widened by these means. Fourteen children with advanced (Stage IV) neuroblastomas were given 100-150 rad TBI in 50 rad daily fractions along with each three-week cycle of standard triple-agent chemotherapy (vincristine, DTIC, cyclophosphamide). Two patients died of toxicity and one is still undergoing therapy. Four of the remaining 12 survive free of disease for 12+ to 31+ months. The regimen is well tolerated, but prolonged, pronounced bone marrow depression, especially thrombocytopenia, commonly occurs after doses of 300-450 rad.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 5016603
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:12
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
SIDE EFFECTS
RADIOTHERAPY
WHOLE-BODY IRRADIATION
BLOOD PLATELETS
CHILDREN
ENDOXAN
FRACTIONATED IRRADIATION
LOW DOSE IRRADIATION
METASTASES
ONCOVIN
AGE GROUPS
ALKALOIDS
ALKYLATING AGENTS
ANIMAL TISSUES
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DRUGS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
TISSUES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)