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Elimination of matrix and spectral interferences in the measurement of lead and cadmium in urine and blood by electrothermal atomic absorption spectrometry with deuterium background correction

Journal Article · · Clinical Chemistry; (United States)
OSTI ID:5016278
; ; ; ;  [1]
  1. University of Antwerp, Department of Nephrology-Hypertension (Belgium)
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Direct measurement of lead and cadmium in blood and urine by electrothermal atomic absorption spectrometry with deuterium background correction (D2-AAS) is prone to severe matrix and spectral interferences. The authors overcame these effects by coating the L'vov platform with ammonium molybdate, reducing the atomization time, introducing a post-atomization cooling step, carefully selecting ashing and atomization temperatures, and using an appropriate procedure for matrix modification. To determine Pb and Cd in blood and urine, they used matrix-matched calibration curves. With the proposed procedure for sample preparation, both Pb and Cd in whole blood can be determined in the same diluted sample. Results obtained by D2-AAS correlate closely with those by Zeeman-corrected AAS. Detection limits (mean blank + 3 SDblank) for Pb in urine and blood were 4 micrograms/L. For cadmium, the detection limits were 0.4 and 0.1 micrograms/L for urine and blood analysis, respectively. Between-run CVs were less than 5.0%.

OSTI ID:
5016278
Journal Information:
Clinical Chemistry; (United States), Journal Name: Clinical Chemistry; (United States) Vol. 37:9; ISSN 0009-9147; ISSN CLCHA
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
ANIMALS
CADMIUM
DEUTERIUM
ELEMENTS
HYDROGEN ISOTOPES
INTERFERENCE
ISOTOPE APPLICATIONS
ISOTOPES
LEAD
LIGHT NUCLEI
MAMMALS
MAN
MEASURING METHODS
METABOLISM
METALS
NUCLEI
ODD-ODD NUCLEI
PRIMATES
SPECTRA
SPECTROPHOTOMETRY
STABLE ISOTOPES
TRACER TECHNIQUES
VERTEBRATES