Effects of prenatal irradiation on fetal, neonate, and young adult murine hemopoiesis

Journal Article · Thu Dec 01 04:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90350-4· OSTI ID:5016090

Weinberg, S R

B6D2F1 mice received cobalt-60 radiation on day 10.5 of gestation at dose of 50 to 300 rad at a dose rate of 40 rad per min. These animals were studied at four selected age periods: day 14.5 of gestation; neonate; juvenile; and 13 week-old adult. Fetal liver cellularity, morphology, and hemopoietic progenitor cell concentration reflected injury after 200 rad. The 15 day-old mouse spleen cellularity was affected more than bone marrow cellularity, but greater radiation injury was reflected by bone marrow hemopoietic progenitor cells. Fluctuations from normal hematopoietic values were greater in the 15 day-old juvenile than in the 9 day-old neonate, commencing with 50 rad. These included peripheral blood parameters and marrow- and spleen-derived erythroid-, granulocytic and megakaryocytic-progenitor cells. The consequences of prenatal irradiation (150 rad) were given evident in the 13 week-old mouse. This was manifested by a reduced spleen cellularity and perturbations in concentration of hemopoietic progenitor cells in the bone marrow.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD
• OSTI ID: 5016090
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9:12; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FETUSES
GAMMA RADIATION
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEONATES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SPLEEN
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES