The chemical properties of silica particle surface in relation to silica-cell interactions

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Journal of Toxicology and Environmental Health; (USA)

DOI:https://doi.org/10.1080/15287398909531314· OSTI ID:5015695

Shi, Xianglin; Dalal, N S ^[1]; Xiang, N Hu ^[2]; Vallyathan, V ^[1]

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1. West Virginia Univ., Morgantown (USA)
2. Shanghai Metallurgical Industry Bureau (China)

Although silicosis has been studied extensively, the mechanism is still not fully understood. Experiments do provide evidence that the actions of unique properties of silica surface on the cell membrane are the starting point of silicotic processes. This paper summarizes literature on chemical properties of silica surface, and the effect of particle size on silica toxicity. This paper also discusses the ways in which silica dusts are though to interact with the cell membrane, with emphasis on freshness, hydrogen bonding, and free-radical interactions.

• OSTI ID: 5015695
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Journal Name: Journal of Toxicology and Environmental Health; (USA) Vol. 27:4; ISSN JTEHD; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CONSTITUENTS
CELL MEMBRANES
CHALCOGENIDES
CHEMICAL PROPERTIES
DISEASES
DUSTS
ETIOLOGY
MEMBRANES
MINERALS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PARTICLE SIZE
PNEUMOCONIOSES
RADICALS
RESPIRATORY SYSTEM DISEASES
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SIZE
TOXICITY