Effects of cysteamine on the hypothalamic-pituitary axis in the rat

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Fed. Proc.; (United States)

OSTI ID:5013769

McComb, D J; Cairns, P D; Kovacs, K; Szabo, S

The effects of cysteamine (CSH) on hypothalamic concentrations of neuropeptides were reviewed and correlated with available information on changes in pituitary hormone content and circulating pituitary hormone levels. In our study, we found notable changes in the morphology of lactotropes from female Long-Evans rats treated for 7 days with CSH (300 mg/(kg X day) per os). Forming granules increased in number, and crinophagy, which is the augmented incorporation of these granules into lysosomes, was evident. Storage granules were reduced in number. These changes were not suppressed by simultaneous administration of 17 beta-estradiol (50 micrograms/day s.c.) for 7 days. CSH administration failed to prevent estrogen-induced lactotrope hyperplasia. Serum prolactin levels were unaffected by CSH treatment. The morphological changes in the adenohypophysis did not resemble those observed when rats were treated with bromocriptine. The rough endoplasmic reticulum luminal density was reduced in gonadotropes from intact CSH-treated rats after 1 wk. CSH treatment suppressed the development of castration cells and significantly reduced serum luteinizing hormone levels in ovariectomized rats. The morphological effects of CSH appeared to be confined to lactotropes and gonadotropes.

• OSTI ID: 5013769
• Journal Information: Fed. Proc.; (United States), Journal Name: Fed. Proc.; (United States) Vol. 9; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BODY
CASTRATION
CELL CONSTITUENTS
CYSTAMINE
DRUGS
ENDOCRINE GLANDS
ENDOPLASMIC RETICULUM
ESTRADIOL
ESTRANES
ESTROGENS
GLANDS
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
LTH
MAMMALS
MEDICINE
MORPHOLOGICAL CHANGES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOIDS
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SOMATOSTATIN
STEROID HORMONES
STEROIDS
SURGERY
ULTRASTRUCTURAL CHANGES
VERTEBRATES