Experimental myocardial ischemia. Pt. 2

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Cardiovasc. Interv. Radiol.; (United States)

DOI:https://doi.org/10.1007/BF02552312· OSTI ID:5011980

Serur, J R; Als, A V; Paulin, S

The comparative effects of meglumine sodium diatrizoate (MSD), sodium meglumine calcium metrizoate (SMCM), and metrizamide (M) were studied in an isolated canine heart preparation. The parameters observed were coronary blood flow (CBF), myocardial contractile force (MCF), positive and negative dF/dt, and perfusion pressure during normal and ischemic perfusion conditions. MSD had an initial negative inotropic effect but baseline MCF returned in 1 min during normal perfusion and 2 min under ischemic conditions. SMCM and M had only a positive inotropic effect under normal perfusion. However, during ischemia, the positive effect of SMCM was followed by a decrease in contractile force. M showed only a positive effect on force during ischemia. Our results indicate that calcium additive may increase the risk of coronary arteriography in patients with severe coronary artery disease.

• OSTI ID: 5011980
• Journal Information: Cardiovasc. Interv. Radiol.; (United States), Journal Name: Cardiovasc. Interv. Radiol.; (United States) Vol. 5:3/4; ISSN CAIRD
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
HEART
INDUSTRIAL RADIOGRAPHY
ISCHEMIA
MAMMALS
MEDICINE
MUSCLES
MYOCARDIUM
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
SIDE EFFECTS
TOXICITY
VASCULAR DISEASES
VERTEBRATES
X-RAY RADIOGRAPHY