Genotoxicity of nitrated polycyclic aromatic hydrocarbons and related structures on Escherichia coli PQ37 (SOS chromotest)
- Univ. of Heidelberg, Mannheim (West Germany)
To determine the genotoxicity of nitrated polycyclic aromatic hydrocarbons and related molecules (nPAH) the authors examined 24 compounds representative of nitroanthracenes, nitrofluorenes, nitronaphthalenes, nitropyrenes, and nitroquinolines for genotoxicity in Escherichia coli PQ37 (SOS-chromotest). To enhance the sensitivity of the tester strain and optimize metabolic activation they used a modified test protocol and S9-mix composition. As expected from previously referred mutagenicity studies, the highest SOS inducing potencies (SOSIP) were exhibited by the dinitropyrenes, 4-nitroquinoline-N-oxide, and 3-nitrofluoranthese. The results were compared to those reported for the bacterial mutagenicity of these substances in Salmonella typhimurium TA98.
- OSTI ID:
- 5011073
- Journal Information:
- Environmental Management; (United States), Journal Name: Environmental Management; (United States) Vol. 18:1; ISSN EMNGD; ISSN 0364-152X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTHRACENE
AROMATICS
AZAARENES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
CONDENSED AROMATICS
ESCHERICHIA COLI
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLYCYCLIC NITRO COMPOUNDS
PYRIDINES
QUINOLINES
SCREENING
STRUCTURE-ACTIVITY RELATIONSHIPS