Inhibitory effect of lichen constituents on mutagenicity induced by heterocyclic amines

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Environmental Management; (United States)

DOI:https://doi.org/10.1002/em.2850180107· OSTI ID:5010993

Osawa, T; Kumon, H; Reece, C A; Shibamoto, T ^[1]

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1. Univ. of California, Davis (United States)

Physodic acid, one of the main constituents of Hypogymnia enteromorpha, inhibited the mutagenicity of indirect mutagens, including benzo(a)pyrene and heterocyclic amines in Salmonella typhimurium TA 98. In contrast, it was not effective against direct mutagens such as 6-nitropiperonal and adriamycin. Its antimutagenicity was not associated with free-radical scavenging or antioxidative activities. Physodic acid seemed to inhibit the formation of reactive metabolites, such as N-hydroxy-Trp-P-2, by blocking the hepatic microsomal oxidation systems. Another component of H. enteromorpha, physodalic acid, also inhibited mutagenicity of a heterocyclic amine, Trp-P-2, in S. typhimurium TA 98, even though it was reportedly mutagenic in S. typhimurium TA 100.

• OSTI ID: 5010993
• Journal Information: Environmental Management; (United States), Journal Name: Environmental Management; (United States) Vol. 18:1; ISSN EMNGD; ISSN 0364-152X
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALGAE
AMINES
ANABOLISM
ANTINEOPLASTIC DRUGS
AROMATICS
BACTERIA
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DRUGS
ESTERS
EUMYCOTA
FUNGI
GENETIC EFFECTS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INHIBITION
LACTONES
LICHENS
LIVER
METABOLISM
MICROORGANISMS
MICROSOMES
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANS
PLANTS
RIBOSOMES
SALMONELLA
SALMONELLA TYPHIMURIUM