Amiodarone-induced hypothyroidism. A common complication of prolonged therapy: a report of eight cases
Amiodarone is a widely used antiarrhythmic drug, which contains 75 mg of iodide per 200 mg of active substance. Eight patients receiving long-term amiodarone therapy became hypothyroid. Seven of these patients had no previous history of thyroid dysfunction or goiter. Antithyroid antibodies were absent, and standard perchlorate discharge tests were positive in seven patients when hypothyroidism was diagnosed. In one patient, amiodarone therapy was withdrawn; over the next nine months, the hypothyroidism resolved, and results of the perchlorate discharge test reverted to normal. The authors conclude that amiodarone-induced hypothyroidism is similar to previously described iodide-induced hypothyroidism. It may develop in the absence of a previous history of thyroid disease, and all patients receiving long-term amiodarone therapy should therefore be regularly monitored for hypothyroidism.
- OSTI ID:
- 5010599
- Journal Information:
- Arch. Intern. Med.; (United States), Journal Name: Arch. Intern. Med.; (United States) Vol. 6; ISSN AIMDA
- Country of Publication:
- United States
- Language:
- English
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560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANTIBODIES
BENZOFURANS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
DIAGNOSIS
DISEASES
DRUGS
ENDOCRINE DISEASES
FURANS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYPOTHYROIDISM
IODIDES
IODINE COMPOUNDS
IODINE ISOTOPES
ISOTOPES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATIENTS
PEPTIDE HORMONES
THYROID HORMONES
THYROXINE
VASODILATORS