Potentiating effects of caffeine on teratogenicity of alkylating agents in mice

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · Teratology; (United States)

DOI:https://doi.org/10.1002/tera.1420280106· OSTI ID:5010253

Fujii, T; Nakatsuka, T

Teratogenic to subteratogenic doses of x-ray, mitomycin C, MNNG, thio-TEPA, cyclophosphamide, and chlorambucil were administered to pregnant ICR mice together with caffeine at doses of 12.5, 25, or 50 mg/kg on day 11 of gestation. Fetuses were examined for gross malformations on day 18 of gestation. The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg. The teratogenicity of chlorambucil was also significantly potentiated by caffeine at 50 mg/kg, but similar potentiation was not observed for x-ray, MNNG, thio-TEPA, and cyclophosphamide.

• Research Organization: Nippon Merck-Banyu Co., Ltd., Saitama-ken, Japan
• OSTI ID: 5010253
• Journal Information: Teratology; (United States), Journal Name: Teratology; (United States) Vol. 28:1; ISSN TJADA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANALEPTICS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PRENATAL EXPOSURE
PURINES
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNERGISM
TERATOGENESIS
VERTEBRATES
X RADIATION
XANTHINES