Genes affecting the expression of cytochrome c in yeast: genetic mapping and genetic interactions
Journal Article
·
· Genetics; (United States)
OSTI ID:5008522
The four mutant genes, cyc2 cyc3, cyc8 and cyc9, that affect the levels of the two iso-cytochromes c in the yeast Saccharomyces cerevisiae have been characterized and mapped. Both cyc2 and cyc3 lower the amount of iso-1-cytochrome c and iso-2-cytochrome c; whereas, cyc8 and cyc9 increase the amount of iso-2-cytochrome c. The cyc2, cyc3, cyc8, and cyc9 genes are located, respectively, on chromosomes XV, I, II, and III, and are, therefore, unlinked to each other and unlinked to CYC1, the structural gene of iso-1-cytochrome c and to CYC7, the structural gene of iso-2-cytochrome c. While some cyc3 mutants are completely or almost completely deficient in cytochromes c, none of the cyc2 mutants contained less than 10% of parental level of cytochrome c. We suggest that cyc2 and cyc3 may be involved with the regulation or maturation of the iso-cytochromes c. In addition to having high levels of iso-2-cytochromes c, the cyc8 and cyc9 mutants are associated with flocculent cells and other abnormal phenotypes. The diverse abnormalities suggest that cyc8 and cyc9 are not simple regulatory mutants controlling iso-2-cytochrome c.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 5008522
- Journal Information:
- Genetics; (United States), Journal Name: Genetics; (United States) Vol. 94:4; ISSN GENTA
- Country of Publication:
- United States
- Language:
- English
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