Continuous blood densitometry - fluid shifts after graded hemorrhage in animals

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Am. J. Physiol.: Heart Circ. Physiol.; (United States)

OSTI ID:5006723

Hinghofer-Szalkay, H

Rapid fluid shifts in four pigs and two dogs subjected to graded hemorrhage are investigated. Arterial blood density (BD), mean arterial pressure (MAP), central venous pressure (CVP), arterial plasma density (PD), hematocrit (Hct) and erythrocyte density were measured. The apparatus and mechancial oscillator technique for measuring density are described. Fluid shifts between red blood cells and blood plasma and alterations in the whole-body-to-large vessel Hct, F(cell) are studied using two models. The bases of the model calculations are discussed. A decrease in MAP, CVP, and BP is detected at the beginning of hemorrhaging; continued bleeding results in further BD decrease correlating with volume displacement. The data reveal that at 15 ml/kg blood loss the mean PD and BD dropped by 0.99 + or - 0.15 and 2.42 + or 0.26 g/liter, respectively, and the Hct dropped by 2.40 + or 0.47 units. The data reveal that inward-shifted fluid has a higher density than normal ultrafiltrate and/or there is a rise in the F(cell) ratio. It is noted that rapid fluid replacement ranged from 5.8 + or - 0.8 to 10.6 + or - 2.0 percent of the initial plasma volume. 32 references.

• Research Organization: NASA, Ames Research Center, Moffett Field, CA; Graz Universitaet, Austria
• OSTI ID: 5006723
• Journal Information: Am. J. Physiol.: Heart Circ. Physiol.; (United States), Journal Name: Am. J. Physiol.: Heart Circ. Physiol.; (United States) Vol. 19; ISSN AJPPD
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BLOOD PRESSURE
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
ERYTHROCYTES
HEMATOLOGY
HEMORRHAGE
HYPOTENSION
MATERIALS
MEDICINE
ORGANS
PATHOLOGICAL CHANGES
SYMPTOMS