Improved five year survival after combined radiotherapy-chemotherapy for Stage I-II non-Hodgkin's lymphoma

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90027-9· OSTI ID:5006387

Monfardini, S; Banfi, A; Bonadonna, G; Rilke, F; Milani, F; Valagussa, P; Lattuada, A

In order to improve the prognosis of patients with localized non-Hodgkin's lymphomas (NHL) who are treated with radiotherapy (RT), a prospective controlled study utilizing a combined modality approach was carried out in patients with pathologic Stage I-II NHL. After treatment with regional RT, patients in complete remission were randomized to receive either no further therapy or 6 cycles of cyclophosphamide, vincristine and prednisolone (CVP). At 5 years from completion of irradiation, the relapse-free survival was 46.3% after RT and 72.1% after RT plus CVP (P=0.005). The corresponding findings for the overall survival calculated from the beginning of irradiation were 55.8 and 82.8% respectively (P=0.03). The favorable effects of adjuvant chemotherapy on relapse-free survival were statistically significant only in the subgroup with diffuse histology. In patients who relapsed after RT alone, the salvage therapy failed to induce a high incidence of second durable remission. Adjuvant chemotherapy is indicated to improve the curve rate in pathologic stage I-II NHL with diffuse histology when regional RT is utilized.

• Research Organization: Istituto Nazionale Tumori, Milan, Italy
• OSTI ID: 5006387
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKYLATING AGENTS
ANIMALS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
CORTICOSTEROIDS
DATA
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSES
DRUGS
ENDOXAN
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FIBROSIS
GASTROINTESTINAL TRACT
GLUCOCORTICOIDS
HISTOLOGY
HORMONES
HYDROXY COMPOUNDS
INFORMATION
INTESTINES
KETONES
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
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PATHOLOGICAL CHANGES
PREDNISOLONE
PREGNANES
PRIMATES
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