Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report

Journal Article · Tue Jul 01 00:00:00 EDT 1980 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.77.7.4221· OSTI ID:5006255

Neel, J V ^[1]; Satoh, C; Hamilton, H B; Otake, M; Goriki, K; Kageoka, T; Fujita, M; Neriishi, S; Asakawa, J

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1. Univ. of Michigan, Ann Arbor

A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of proximally exposed parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of distally exposed parents, who had essentially no radiation exposure.

• OSTI ID: 5006255
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 77:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
A-BOMB SURVIVORS
GENETIC RADIATION EFFECTS
CHILDREN
PROTEINS
GENETIC VARIABILITY
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
ELECTROPHORESIS
EPIDEMIOLOGY
GENES
HIROSHIMA
MOLECULAR STRUCTURE
MUTATIONS
NAGASAKI
PHENOTYPE
RADIATION DOSES
AGE GROUPS
ANIMALS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
DOSES
GENETIC EFFECTS
JAPAN
MAMMALS
MAN
ORGANIC COMPOUNDS
PRIMATES
RADIATION EFFECTS
VERTEBRATES
560151* - Radiation Effects on Animals- Man
550400 - Genetics
550200 - Biochemistry