Influence of selenium on the metabolism of bromobenzene and a possible relationship to its hepatotoxicity

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(85)90113-6· OSTI ID:5001405

Chakrabarti, S; Brodeur, J

When male Sprague-Dawley rats were treated with sodium selenite (1 mg/kg, sc) 24 hr prior to or simultaneously with bromobenzene (2.5 mmol/kg, ip) and sacrificed 48 hr after the bromobenzene dose, increased levels of the activities of serum transaminases induced in the bromobenzene treated rats were significantly reduced in the presence of selenium. However, no such reduction in the transaminases activities were observed when rats were either pretreated with selenite for 48 hr or pretreated with 0.1, 0.2, or 0.5 mg/kg of selenite. Although selenium alone had no effect on the hepatic microsomal drug metabolism, simultaneous treatment of selenite (1 mg/kg) with bromobenzene resulted in only an increase in the activity of aniline hydroxylase after 48 hr as compared to that in the bromobenzene-treated group. When rats were given 2.5, 10, and 20 ppm of selenite in drinking water daily for 4 weeks prior to an ip injection of 2.5 mmol/kg of bromobenzene and were sacrificed 48 hr after bromobenzene administration, a reduction in the SGOT activities in all the pretreated groups and a reduction of SGPT activity in 20 ppm selenite-treated group were observed when compared with those in the bromobenzene-treated groups. A dose-dependent increase in hepatic GSH concentrations were observed due to such chronic selenium treatment. Treatment with selenite (1 mg/kg) 24 hr prior to bromobenzene injection (2.5 mmol/kg) increased initially both o and p-bromophenols in the rat urine at 0-7.5 hr without affecting urinary thioethers. On the contrary, the ratio of thioethers to p-bromophenol was significantly higher in both 2.5 and 10 ppm selenite-pretreated (4 weeks) rats as well as a significant increase in the ratio of thioethers to total phenolic metabolites in 10 ppm and an increase close to significant in 2.5 ppm selenite-treated rats were observed initially at 0-7.5 hr urine samples.

• Research Organization: Universite de Montreal, Quebec
• OSTI ID: 5001405
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 37:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINOTRANSFERASES
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL EFFECTS
BODY
BROMINE COMPOUNDS
DATA
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
GLANDS
HALOGEN COMPOUNDS
HYDROCARBONS
INFORMATION
INJURIES
LIVER
MAMMALS
METABOLISM
NITROGEN TRANSFERASES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SELENIUM
SEMIMETALS
TOXICITY
TRANSFERASES
VERTEBRATES