Increased caries-incidence by oral inoculation of cariogenic bacteria in rats after dietary fluoride
The authors had previously observed that dietary NaF administered to rats during the formative and eruptive stages of tooth development does not significantly reduce the enamel solubility in acid buffer solution. They hypothesized that NaF reduces the cariogenicity of the bacterial flora. In order to test this hypothesis, rats from the same litter were divided into three groups all of which received a cariogenic diet. Group one received no fluoride. Groups two and three were supplemented with 50 ppm NaF, from day 1 to day 21. In the first study, one of the 21-day-old NaF-supplemented groups was inoculated by smears of fecal material from the control animals that did not receive NaF supplement. The second NaF group was not inoculated and served as control. In a second study, cariogenic Strep. mutans 6715 was used as the inoculum in place of the fecal smear. In both studies, the inoculation of a NaF group increased the caries to about 70% of the control group, while the mean scores on the non-inoculated NaF group were about 50% of the control group. These results indicate that alteration of the transmissible flora may be an important factor in the cariostatic action of dietary fluoride in experimental animals. This observation supports the suggestion that fluoride may alter the cariogenic flora.
- Research Organization:
- Emory Univ. School of Dentistry, Atlanta, GA
- OSTI ID:
- 5000124
- Journal Information:
- Fluoride; (United States), Vol. 9:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FLUORIDES
BIOLOGICAL EFFECTS
STREPTOCOCCUS
SPECIES DIVERSITY
CARIES
DENTISTRY
DIET
FECES
RATS
SODIUM FLUORIDES
TEETH
ALKALI METAL COMPOUNDS
ANIMALS
BACTERIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
DIGESTIVE SYSTEM
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MATERIALS
MEDICINE
MICROORGANISMS
ORAL CAVITY
PATHOLOGICAL CHANGES
RODENTS
SODIUM COMPOUNDS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)