Effect of $gamma$ radiation on uracil and uridylic acid in aerated aqueous solution (in French)
Thesis. In the first part of this thesis, an aerated aqueous uracil solution exposed to gamma radiation was studied. Eleven radiolysis products were identified. The spectral properties (IR, NMR, and mass spectrometry) of these substances are described and discussed. Chromatographic separation techniques were developed for separating these often unstable products under favorable conditions. lntermediate radiolysis products (hydroxyhydroperoxides) were prepared and identified. Studies of the degradation kinetics of uracil and the G value for the radiolysis products enabled the amounts of these substances produced to be established. The decay scheme for the radiolysis substances was determined. Up until now, it was believed that the principal products resulted from a saturation of the 5-6 double bond of the pyrimidine cycle. It was shown that this is not the only mechanism occurring and that there is also an opening of the pyrimidine cycle. In the second part of this thesis, the principal products produced by the rupturing of the N-glycosidic bond of uridylic acid were identified. (FR)
- Research Organization:
- Grenoble-1 Univ., 38 (France)
- Sponsoring Organization:
- Sponsor not identified
- NSA Number:
- NSA-29-026655
- OSTI ID:
- 4938862
- Report Number(s):
- FRNC-TH--471
- Country of Publication:
- France
- Language:
- French
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