The d4 gene family in the human genome

Journal Article · Thu Aug 15 04:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0440· OSTI ID:484340

Chestkov, A V; Baka, I D; Kost, M V ^[1]

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1. Engelhardt Inst. of Molecular Biology, Moscow (Russian Federation); and others

The d4 domain, a novel zinc finger-like structural motif, was first revealed in the rat neuro-d4 protein. Here we demonstrate that the d4 domain is conserved in evolution and that three related genes form a d4 family in the human genome. The human neuro-d4 is very similar to rat neuro-d4 at both the amino acid and the nucleotide levels. Moreover, the same splice variants have been detected among rat and human neuro-d4 transcripts. This gene has been localized on chromosome 19, and two other genes, members of the d4 family isolated by screening of the human genomic library at low stringency, have been mapped to chromosomes 11 and 14. The gene on chromosome 11 is the homolog of the ubiquitously expressed mouse gene ubi-d4/requiem, which is required for cell death after deprivation of trophic factors. A gene with a conserved d4 domain has been found in the genome of the nematode Caenorhabditis elegans. The conservation of d4 proteins from nematodes to vertebrates suggests that they have a general importance, but a diversity of d4 proteins expressed in vertebrate nervous systems suggests that some family members have special functions. 11 refs., 2 figs.

• OSTI ID: 484340
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 36; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACID SEQUENCE
B CODES
BIOLOGICAL EVOLUTION
COSMIDS
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
ETIOLOGY
FLUORESCENCE
GENE REGULATION
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 14
HUMAN CHROMOSOME 19
HUMAN CHROMOSOMES
NUCLEOTIDES
POLYMERASE CHAIN REACTION
PROBES
PROTEINS
RATS
SPLICING
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION