Urethan Induction of Thymic Lymphoma in C57bl Mice
Studies were made on the induction of thymic lymphoma in C57b1 mice by urethan alone. Urethan was injected subcutaneously into mice less than 24 hr old at a dose of 1 mg/g body weight, and seven further injections at the same dose were given at weekly intervals. Tumors were found in 12 of the 13 surviving at ages between 12 and 27 weeks, and disseminstion was found in 7 of the 12. The tumors were identical histologically with those induced by irradiation. The same weekly urethan dose was injected intraperitoneally into C57b1 mice for a total of 4 treatments, beginning at 4 to 5 weeks of age; only one of 19 mice developed lymphoma at 10 months. No lymphoid tumors were found in 30 untreated mice up to 1 year old. (D.L.C.)
- Research Organization:
- Stanford Univ., Palo Alto, Calif.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-020074
- OSTI ID:
- 4839583
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4828 Vol. 194; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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