THE EFFECT OF RADIATION AND POLYMYXIN B SULFATE ON THE SERIUM BETA- GLUCURONIDASE ACTIVITY LEVEL IN CANCER PATIENTS: A PRELIMINARY REPORT
Journal Article
·
· Ann. Chir. Gynaecol. Fenniae
OSTI ID:4839385
Serial serum BETA -glucuronidase activity determinations showed a consistently higher level in 50 cancer patients as compared with a group of healthy adults. In 1 group of these patients treated with radiation alone, the serum BETA glucuronidase level rose in all reaching the highest peak about the 12th day. Another group of these cancer patients was treated with radiation and polymyxin B each day for 2 consecutive days. In all, the serum activity showed a sharp fall after the 2nd injection which was followed by clinical improvement. In order to exclude the possibility of a direct deactivating effect of radiation of BETA -glucuronidase in the circulating blood, the following in vitro experiments were performed. A pure crystalline enzyme was dissolved in distilled water to an approximately similar concentration to that found in cancer patients' serums with and without polymyxin and exposed to 50,000 r radiation. This did not lower the enzyme activity level. Pleural fluid from cancer patients showing high BETA -glucoronidase activity, with and without polymyxin, exposed to a similar dose of radiation showed no change in activity. (H.H.D.)
- Research Organization:
- Johns Hopkins Univ., Baltimore
- NSA Number:
- NSA-16-020258
- OSTI ID:
- 4839385
- Journal Information:
- Ann. Chir. Gynaecol. Fenniae, Journal Name: Ann. Chir. Gynaecol. Fenniae Vol. Vol: 51
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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