THE ROLE OF ANTIBODY IN RECOVERY FROM INFECTION WITH VACCINIA VIRUS
The effect of x irradiation on recovery of guinea pigs infected with vaccinia virus was investigated. The animals were irradiated 24 hrs before infection with 300 r, a dose found to inhibit antibody response but not development of delayed skin sensitivity. The sequence of events following infection was the same as in unirradiated animals except that antibody could not be detected in serum up to 28 days after infection nor at any time in the lesion. Circulating antibody could be detected by the 38th day in irradiated animals, and delayed skin sensitivity was present as early as the 4th day. The results show that neutralizing antibody is not necessary for recovery from vaccinia infection and do not rule out the possibility that delayed hypersensitivity (or interferon) may be factors in recovery. (H.H.D.)
- Research Organization:
- National Institutes of Health, Bethesda, Md.
- NSA Number:
- NSA-16-020270
- OSTI ID:
- 4839382
- Journal Information:
- Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 87; ISSN JOIMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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