THE COMBINED PROTECTIVE EFFECT OF CYSTEAMINE AND GLYCERINE IN X-IRRADIATED T1 PHAGES

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Zeitschrift fuer Naturforschung (West Germany) Divided into Z. Nautrforsch., A, and Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,

OSTI ID:4839336

Hotz, G

The plaque forming ability of coliphage T1 suspended in glycerol solutions was inactivated by x rays. A marked decrease in radiosensitivity was observed which was highest at a glycerol molarity of 10. At higher concentrations the protective effect decreases but this decrease could be avoided by adding cysteamine before irradiation. It was found that the protection afforded by 0.15 M cysteamine was additive to that observed with glycerol from zero concentration to 10 M. The highest ratio of sensitivity obtained was 6 as observed between T1 phage suspended in a cysteamine-- glycerol-- broth mixture and broth-suspended T1 without any addition. Tentative explanations are given for the remarkably efficient radioprotective actions found and some consequences thereof for further work are indicated. (auth)

• Research Organization: Kernforschungszentrum, Karlsruhe, Ger.
• NSA Number: NSA-16-020294
• OSTI ID: 4839336
• Journal Information: Zeitschrift fuer Naturforschung (West Germany) Divided into Z. Nautrforsch., A, and Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, Journal Name: Zeitschrift fuer Naturforschung (West Germany) Divided into Z. Nautrforsch., A, and Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys., Vol. Vol: 17b; ISSN ZNTFA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ALCOHOLS
BACTERIOPHAGES
BIOLOGY AND MEDICINE
CHEMICALS
CYSTEAMINE
GLYCERIN
RADIATION PROTECTION
RADIOSENSITIVITY
X RADIATION