ACTION OF X RADIATION ON ADRENERGIC TRANSMISSION

Journal Article · Thu Feb 01 04:00:00 EST 1962 · Arch intern. physiol. et biochim.

OSTI ID:4829339

Bacq, Z M; Beaumariage, M L

Contractions of the nictitating membrane of anesthetized cats produced by electrical stimulation were recorded during x irradiation of pre- and postganglionic fibers and ganglionic synapse. Brief irradiation with 190-650 r per min, directed toward the center of the membrane, did not modify the response of the smooth muscle to preganglionic stimulation. However, 10-30 min following doses of 10,00040,000 r, an increased response to neural excitation was noted that paralleled the increased sensitivity to infravenous injection of adrenaline or nonadrenaline. Adrenalectomy did not modify these responses, and thus irradiation does not act in this instance by stimulation of the pituitaryadrenal system. The radioresistance of the nictitating membrane and adrenergic transmission is very high; function was maintained even with doses of 1,000,000 r delivered over 8 min or repeated doses of 100,000 over an 8-hr period. (H.H.D.)

• Research Organization: Centre Natl. Radiobiol. et Genetique, Liege
• NSA Number: NSA-16-020143
• OSTI ID: 4829339
• Journal Information: Arch intern. physiol. et biochim., Journal Name: Arch intern. physiol. et biochim. Vol. Vol: 70
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ADRENAL GLANDS
ADRENALINE
ANESTHESIA
ANIMALS
BIOLOGY AND MEDICINE
CATS
ELECTRIC POTENTIAL
EYES
HORMONES
MUSCLES
NERVOUS SYSTEM
PHYSIOLOGY
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
SENSITIVITY
SURGERY
X RADIATION