EFFECTS OF WHOLE-BODY X-IRRADIATION ON THE ADRENAL GLAND IN WHITE RATS. II. MORPHOLOGICAL CHANGES IN THE ADRENAL GLAND, THYMUS, OVARY AND HYPOPHYSIS

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Hiroshima Igaku (Japan)

OSTI ID:4829026

Ishibashi, I

Normal mature female whlte rats (of the same litter) were irradiated with a single dose of 300, 600, and 1200 r and were examined histologically and histochemically. Adrenal gland The 300-r exposed group showed mild degeneration and destructive changes in the glomerular layer cells 3 hours after irradiation. These, however, returned almost to the former normal state at 3 to 7 days after irradiation. The 600-r exposed group showed more severe pathological changes with continuing increase in lipid granules at 3 to 7 days after irradiation. The 1200-r exposed group showed only fine granules in the zona glomerulosa and zona fasciculata and 7 days later hardly any lipid granules were present in any of the cortical layers. The 1200-r exposed group showed, from 24 hours after irradiation, diffuse proliferation of the zona fasciculata and swelling of the cells. Thymus: The 300-r exposed group and thereafter the changes became more marked with lapse of time. The boundary between the cortex and the medulla became indistinct and a considerable decrease was noted in the thymus cells. In the 600 r and 1200 r exposed group, almost all thymus cells disappeared from the cortex and medulla and the reticular cells becanie degenerated with considerable hyperemia and congestion following the irration was considerable; RNA in each exposed group, however, remained unchanged. The ovary: In the 600 and 1200 r exposed groups, almost all primitive ovicapsules and graafian follicles were destroyed and the corpus luteum became atrophied to a small size with marked congestion, though in the 300-r group these effects were less severe. The 300 r group showed a tendency toward recovery from about 3 days after the irradiation. The 600 decrease. The pituitary glandi Each group showed slight degeneration of the cells, marked hyperemia, and congestion in the insterstltium and a tendency to a slight increas0 in the alpha -cells and a decrease in the beta -cells. (Abstr. japan. Med., 1: No. 13, 1961)

• Research Organization: Hiroshima Univ.
• NSA Number: NSA-16-004051
• OSTI ID: 4829026
• Journal Information: Hiroshima Igaku (Japan), Journal Name: Hiroshima Igaku (Japan) Vol. Vol: 13: No. 1, (Spec. Issue); ISSN HIRGA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD VESSELS
CYTOLOGY
GLANDS
GONADS
HYPOPHYSIS
LIPIDS
NUCLEIC ACIDS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RATS
RECOVERY
RIBONUCLEIC ACID
THYMUS
X RADIATION