Influence of energy and dose rate on the responses of rat embryos to radiation

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · Radiology (U.S.)

DOI:https://doi.org/10.1148/79.2.302· OSTI ID:4828393

Sikov, M R; Lofstrom, J E

Rats at various stages of gestation were exposed to graded doses of x rays or gamma rays from 110 to 450 r, in both acute and protracted exposures. The animals were sacrificed after fourteen days of gestation and the results of the production of death and malformation in the fetuses. In general, it was found that a lesser effect was produced by gamma radiation than by physically equivalent doses of x rays. This usually resulted in RBE values in the accepted range (0.80 to 0.95), although substantially lower values (0.41 to 0.63) were found for anomalies of the head after irradiation at nine and a half days of gestation. There was also a reduction in the magnitude of some effects as well as increased values of RBE when protracted exposures were used. The clinical and theoretical importance of these differences are discussed.

• Research Organization: Wayne State Univ. Coll. of Medicine, Detroit; and Detroit Memorial Hospital
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-025231
• OSTI ID: 4828393
• Journal Information: Radiology (U.S.), Journal Name: Radiology (U.S.) Vol. Vol: 79; ISSN RADLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FETUSES
GAMMA RADIATION
MALFORMATIONS
PREGNANCY
RADIATION DOSES
RADIATION EFFECTS
RATS
X RADIATION