Atrophic nerve fibers in regions of reduced MIBG uptake in doxorubicin cardiomyopathy

Journal Article · Wed Nov 01 00:00:00 EST 1995 · Journal of Nuclear Medicine

OSTI ID:482540

Takano, Hajime; Hideyuki, Ozawa; Kobayashi, Isao ^[1]

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1. Yamanashi Medical Univ. (Japan); and others

A myocardial MIBG-SPECT examination was conducted 2 wk after doxorubicin chemotherapy on a 52-yr-old woman without cardiac symptoms. Despite normal {sup 201}Tl scintigraphy, reduced MIBG uptake was detected in the apical anterior, inferior and lateral segments of the left ventricle. The patient died of congestive heart failure due to doxorubicin-induced cardiomyopathy 10 mo later. At necropsy, the left ventricle was markedly dilated and the apical anterior, inferior and lateral walls were thin, stiff and whitish. Nerve fibers in the apical inferior wall were atrophic and markedly fibrotic where MIBG uptake was most reduced. Nerve fibers in the septum were normal where MIBG uptake had remained normal. The histologic findings correspond with the findings on the MIBG image. MIBG imaging may detect cardiac sympathetic denervation in doxorubicin-induced cardiomyopathy before cardiac symptoms are manifest and cardiac function deteriorates. 5 refs., 2 figs.

• OSTI ID: 482540
• Journal Information: Journal of Nuclear Medicine, Vol. 36, Issue 11; Other Information: PBD: Nov 1995
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
55 BIOLOGY AND MEDICINE
BASIC STUDIES
NERVES
ATROPHY
FIBROSIS
MIBG
UPTAKE
DOXORUBICIN
BIOLOGICAL EFFECTS
PATIENTS
CARDIOVASCULAR DISEASES
CHEMOTHERAPY
DIAGNOSTIC TECHNIQUES
EVALUATION
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
IODINE 123
THALLIUM 201
SCINTISCANNING