Scintigraphic assessment of cardiac adrenergic innervation in patients with essential hypertension

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Journal of Cardiovascular Pharmacology; (United States)

DOI:https://doi.org/10.1097/00005344-199117002-00036· OSTI ID:5028631

Fujiwara, Y; Hamada, M; Shigematsu, Y; Sumimoto, T; Hamamoto, K; Hiwada, K ^[1]

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1. 2nd Department of Internal Medicine, Ehime University School of Medicine (Japan)

To assess the regional cardiac adrenergic innervation in patients with essential hypertension (EHT), simultaneous iodine-123 metaiodobenzylguanidine ((123I)MIBG) and thallium-201 (201Tl) myocardial imagings were performed in five patients with EHT, seven patients with hypertrophic cardiomyopathy (HCM), and seven normal subjects. Short axial images at rest were divided into five segments: anterior, septal, posterior, lateral, and apical segments. Percent regional uptake (%RU) of 201Tl except the septal segment in patients with EHT showed no significant difference. However, the %RU of (123I)MIBG at posterior, lateral, and apical segments was significantly lower than that at anterior and septal segments in EHT. This intraimage heterogeneity of (123I)MIBG was also observed in HCM. These results suggest that there is a difference in regional adrenergic innervation of the left ventricle with myocardial hypertrophy.

• OSTI ID: 5028631
• Journal Information: Journal of Cardiovascular Pharmacology; (United States), Journal Name: Journal of Cardiovascular Pharmacology; (United States) Vol. 17 Suppl 2; ISSN 0160-2246; ISSN JCPCD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SYMPATHOLYTICS
SYMPTOMS
THALLIUM 201
THALLIUM ISOTOPES
VASCULAR DISEASES