IN VIVO MEASUREMENT BY THE WHOLE-BODY GAMMA SPECTROMETER OF THE DEGRADATION RATE OF I$sup 131$-LABELED NORMAL ALBUMIN

Journal Article · Mon May 01 04:00:00 EDT 1961 · Laboratory Investigation (U.S.)

OSTI ID:4819815

Lippincott, S W; Cohn, S H; Robertson, J S; Farr, L E

fe of I/sup 131/-labeled albumin in the body through the use of the in vivo whole-body gamma spectrometer. The results obtained by this technic compare very well with those obtained by calculation from serum and urinary excretion radioactivtty concentrattons. It is evident from previous work that to obtain a valid biologic half-life for albumin, observations must be made over a sufficiently long period to permit the ultimate slope of the curve to appear. For such a longterm study, the whole-body counting method provides the only technic consistent with the use of low levels of tracer materials. The advantages of the whole-body counting method are the elimination of serial blood sampling and collection of excreta for radiochemical analysis, direct determination of body content rather than estimation by difference or extrapolation from fractional measurement, and utilization for tracer studies of very low levels of an internally deposited gamma emitter over long periods. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y.
• NSA Number: NSA-16-007394
• OSTI ID: 4819815
• Journal Information: Laboratory Investigation (U.S.), Journal Name: Laboratory Investigation (U.S.) Vol. Vol: 10; ISSN LAINA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALBUMINS
BIOLOGY AND MEDICINE
BLOOD SERUM
GAMMA SPECTROMETERS
HALF-LIFE
IODINE 131
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIOACTIVITY
RADIOCHEMISTRY
TRACER TECHNIQUES
URINE