A Comparison of the Distribution of Radioactive Fluorine and Calcium by Use of Double-Isotope Autoradiography
The autoradiographic distribution picture was compared in whole pregnant mice and young rats at short intervals after the injection of fluorine (NaF¹⁸) and calcium (Ca⁴⁵ Cl²) The isotopes were injected intravenously on the same animal and selective registration of F/sup 18/ and Ca/sup 45/ was made utilizing the great difference in decay rates. Both isotopes especially Ca⁴⁵ were rapidly taken up from the blood. F¹⁸ accumulated more rapidly and selectively in hard tissues while Ca⁴⁵ was taken up in appreciable amounts in some soft tissues. The distribution pattern in bone and in dentine was very similar for F¹⁸ and Ca⁴⁵ F¹⁸ was taken up in proportionately low concentration in the calcifying molar enamel. Ca⁴⁵, but not F¹⁸, was taken up in the cartilage of young animals. A remarkably high accumulation of Ca⁴⁵ was seen in some groups of striated muscles. These muscle groups may be those which were contracted when the lightly anesthetized animal was sacrificed by immersion in the freezing mixture. The dominating excretory organ for F¹⁸ was the kidney while high concentrations of Ca⁴⁵ appeared in the mucosa and contents of the small intestine. (auth)
- Research Organization:
- Royal Veterinary Coll., Stockholm; and Royal Dental School, Stockholm
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-008488
- OSTI ID:
- 4817488
- Journal Information:
- Acta Physiologica Scandinavica, Journal Name: Acta Physiologica Scandinavica Journal Issue: 3-4 Vol. 53; ISSN 0001-6772
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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