THE HISTOGENESIS OF RADIATION-INDUCED (Sr$sup 90$) SQUAMOUS EPITHELIAL CARCINOMA IN RAT LUNG. 1. CHANGES IN BRONCHIAL EPITHELIUM

Journal Article · Fri Dec 01 04:00:00 EST 1961 · Beitr. pathol. Anat. allgem. Pathol.

OSTI ID:4816915

Altmann, H -W; Lick, R; Stutz, E

Changes in bronchial epithelium were followed over a 6-month period in the lung of rats implanted with plexiglas capsules containing a mixture of Sr/sup 90/ and Y/sup 90/. In bronchi of all calibers, squamous epithelial carcinomas arose from a process which began as basal cell hyperplasia, leading to a replacement of the normal cylindrical epithelial cells. Metaplasia and neoplasia of bronchial epithelium under the influence of Sr/sup 90/ radiation is visualized as proceeding via the following steps: normal cylindrical epithelium -- basal cell hyperplasia yields transitional epithelium yields resting squamous epithelium yields proliferating squamous epithelium yields invasive carcinoma. Carcinomas developed most rapidly in proximity to the radiation source. (H.H.D.)

• Research Organization: Universitat, Wurzburg, Ger.
• NSA Number: NSA-16-020147
• OSTI ID: 4816915
• Journal Information: Beitr. pathol. Anat. allgem. Pathol., Journal Name: Beitr. pathol. Anat. allgem. Pathol. Vol. Vol: 125
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BRONCHI
CANCER
CARCINOGENESIS
CYTOLOGY
LUNGS
RADIATION EFFECTS
RADIATION INJURIES
RATS
STRONTIUM 90
TISSUES
YTTRIUM 90