A BIOLOGICAL PRINCIPLE AND ITS CONVERSE: SOME IMPLICATIONS FOR CARCINOGENESIS
The relationship of somatic and inherited mutations in carcinogenesis is discussed, and the generalization is made that where the etiology of a neoplasm involves somatic nuclear gene mutations, individual tumors will be found in which inherited mutations have substituted for somatic. The converse should also be valid, i.e., where Mendelian inheritance of a neoplasm can be demonstrated, somatic mutations should also contribute to its genesis. An analysis of the etiology of human leukemias is attempted, and conclusions are given on both child and adult leukemias. The mechanisms of radiogenic leukemias at Hiroshima and Nagasaki are considered along with leukemia from background radiation. (D.L.C.)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-025106
- OSTI ID:
- 4804702
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 195
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Cancer in atomic bomb survivors
ON THE PROBLEM OF CARCINOGENESIS BY ROENTGEN AND GAMMA RAYS
RADIATIONS AND CARCINOGENESIS
Book
·
Tue Dec 31 23:00:00 EST 1985
·
OSTI ID:6934011
ON THE PROBLEM OF CARCINOGENESIS BY ROENTGEN AND GAMMA RAYS
Journal Article
·
Fri Feb 24 23:00:00 EST 1961
· Wien. Med. Wochschr.
·
OSTI ID:4644725
RADIATIONS AND CARCINOGENESIS
Journal Article
·
Thu Nov 30 23:00:00 EST 1961
· J. Med. Soc. New Jersey
·
OSTI ID:4741571