INTERNAL DISTRIBUTION OF URANIUM COMPOUNDS IN THE BODY AND ACUTE URANIUM POISONING. (English Text)

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Nagoya Journal of Medical Science (Japan)

OSTI ID:4804645

Kitabatake, T; Mizutani, Y

Uranium in animals was measured by counting the betarays emitted. Uranium concentration in the blood was maximum 6 hours after injection, and then gradually decreased. Deposition in the liver. spleen, adrenal glands, and muscles paralleled the blood level. In the kidneys, however, uranium fragmentation gradually increased with time until it reached up to 9% of the injected dose at the end of 48 hours. The same tendency was also seen in the bones. Rats injected intraperitoneally with 0.05 mg of soluble uranium all died within about 30 hours. Microscopically, moderate hyperemia, bleeding in the stroma, and hyaline degeneration of the epithelial cells in the renal tubules were seen in the kidneys. In the group injected with 0.001 mg, renal changes were very slight, and complete recovery took place after about 3 weeks. Rabbits exposed to inhalation of 1000 or 300 mg of insoluble uranium died after 4 to 7 days. However, rabbits inhaling 100 mg survived for more than 4 months, with normal growth rate and hematological findings. Four months after the treatment, one of these rabbits was sacrificed and examined microscopically, but no definite changes were found in the lungs or kidneys. In the heart muscles of rabbits inhaling 100 mg of insoluble uranium some alpha-tracks were detected radioautographically, indicating that some uranium dust may have been taken up into the blood stream. (Abstr. Japan Med., 2: No. 6, June 1962)

• Research Organization: Nagoya Univ. School of Medicine, Japan
• NSA Number: NSA-16-025158
• OSTI ID: 4804645
• Journal Information: Nagoya Journal of Medical Science (Japan), Journal Name: Nagoya Journal of Medical Science (Japan) Vol. Vol: 24: No. 2; ISSN NJMSA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
ANIMALS
BETA DECAY
BIOLOGY AND MEDICINE
BLOOD
BONES
DUSTS
HEART
HEMORRHAGE
KIDNEYS
LIFETIME
LIVER
LUNGS
MUSCLES
QUANTITY RATIO
RADIATION DETECTORS
RADIOAUTOGRAPHY
RATS
SPLEEN
TOXICITY
URANIUM COMPOUNDS