EXPERIMENTAL STUDY ON URANIUM POISONING
Journal Article
·
· Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
OSTI ID:4044906
Rats injected with 0.05 mg/g of soluble uranium (uranyl ritrate hexahydrate) intra-peritoneally all died within 30 hr after the injection. Microscopically moderate hyperaemia and bleeding in the stroma and hyaline degeneration of the epithelial cells of the tubuli were seen in the kidney. In the group injected with less U, the survival time after the injection was increased. These changes seen in rats are considered to result from the chemical toxicity of uranium compounds rather than from radiation energy. In the group injected with 0.001 mg/g of U, renal changes were very slight and almost complete recovery was observed after about 3 weeks. One thousand mg and 300 mg of insoluble U was administered by inhalation into the lungs of adult rabbits. They died in 4 to 7 days after the inhalation. Microscopic examination of the lungs showed moderate to severe lymphocytic and slight leukocytic infiltration with moderate proliferation of the septal cells, mainly around the deposited U dusts. Exudation also was present. Rabbits inhaling 100 mg of insoluble U survived over 4 months. No loss of weight or hematological changes were seen. About 4 months after the inhalation, one of these rabbits was sacrificed and examined microscopically. No severe changes were demonstrated in lungs and kidneys. In the heart muscle of rabbits inhaling 1000 mg of insoluble U, some alpha tracks were recognized radioautographically, an indication that some of the U dusts might have been taken into the blood stream. (Absts. Japan. Med., 1: No. 7, 1960.)
- Research Organization:
- Nagoya Univ., Japan
- NSA Number:
- NSA-15-021982
- OSTI ID:
- 4044906
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
INTERNAL DISTRIBUTION OF URANIUM COMPOUNDS IN THE BODY AND ACUTE URANIUM POISONING. (English Text)
THE CHEMICAL TOXICITY OF THORIUM DIOXIDE FOLLOWING INHALATION BY LABORATORY ANIMALS
MALIGNANT VASCULAR TUMORS IN RABBITS INJECTED INTRAVENOUSLY WITH COLLOIDAL THORIUM DIOXIDE
Journal Article
·
Sat Dec 31 23:00:00 EST 1960
· Nagoya Journal of Medical Science (Japan)
·
OSTI ID:4804645
THE CHEMICAL TOXICITY OF THORIUM DIOXIDE FOLLOWING INHALATION BY LABORATORY ANIMALS
Technical Report
·
Thu Dec 31 23:00:00 EST 1959
·
OSTI ID:4188388
MALIGNANT VASCULAR TUMORS IN RABBITS INJECTED INTRAVENOUSLY WITH COLLOIDAL THORIUM DIOXIDE
Journal Article
·
Sun Dec 31 23:00:00 EST 1961
· Pathologia et Microbiologia (Switzerland) Changed to Exp. Cell Biol.
·
OSTI ID:4657556