Toxic and Protective Effects of AET upon Normal and Irradiated Female Rats
The toxicity and pathologic effects of acute doses of AET-DiBr were examined in rats. The compound is highly toxic to rats, but only local pathological change has been observed. The chronic effects of AET-DiBr have been examined by means of serial intraperitoneal injections. At low doses, large total amounts of the drug can be tolerated. Significant protection against ionizing radiation from Co/sup 60/ was demonstrated in female rats given the drug AET. AET is a more effective radio protectant when given by intraperitoneal injection than when administered orally. In orally-treated animals, a radiation dose-rate effect has been observed. AET affords less protection to animals irradiated at lower doserates.
- Research Organization:
- USAF Aerospace Medical Center (ATC), Brooks AFB, Tex.; Univ. of Texas, Austin; and U.S. Air Force, Austin, Tex.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-026871
- OSTI ID:
- 4804607
- Journal Information:
- British Journal of Radiology, Journal Name: British Journal of Radiology Journal Issue: 416 Vol. 35; ISSN 0007-1285
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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