Pituitary Effect on Synthesis of Deoxyribonucleic Acid in Regenerating Rat Liver following Whole-body X-irradiation

Journal Article · Sat Dec 30 04:00:00 EST 1961 · Nature (London)

DOI:https://doi.org/10.1038/1921309a0· OSTI ID:4802815

GOULD, D. M.; FLOYD, K. W.; WHITEHEAD, R. W.; SANDERS, J. L.

The results of experiments on rats show that under conditions in which synthesis of DNA is active (19 hr postoperative), 750 r delivered either to the whole body or to the head will suppress synthesis of DNA in regenerating liver. Head shielding resulted in a markedly reduced synthesis and the administration of pituitary hormones immediately following irradiation further abolished DNA synthesis. lt is concluded that irradiation of the head alone produced the same inhibition of DNA synthesis in regenerating liver as whole-body irradiation, and that DNA synthesis, although reduced, was present when the head was shielded. It is suggested that the reduction of DNA synthesis in animals with their heads shielded may be the result of adrenal stimulation following x irradiation.

• Research Organization: Univ. of Colorado Medical School, Denver
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-007464
• OSTI ID: 4802815
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4809 Vol. 192; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
BIOCHEMISTRY
BRAIN
GLANDS
HORMONES
LIVER
NUCLEIC ACIDS
PITUITARY GLAND
RADIATION DOSES
RATS
REGENERATION
SHIELDING
X RADIATION