Action of Low Doses of Ionizing Radiations on the Electrophoretic Mobility of Ehrlich Ascites Tumour Cells

Journal Article · Sat Jan 20 04:00:00 EST 1962 · Nature (London)

DOI:https://doi.org/10.1038/193238a0· OSTI ID:4801146

STEIN, G.; SEAMAN, G. V. F.; HEARD, D. H.

When standard washed Ehrlich ascites tumor cells were irradiated with small doses of gamma or x rays, it was found that as the dose increased, the electrophoretic mobility also increased up to a maximum value. Standard washed cells which were irradiated prior to washing in the presence of ascitic fluid immediately after its withdrawal from the mouse gave the same results, as also did washed cells which were obtained from a mouse immediately after it was subjected to various doses of whole-body irradiation. When irradiation, at a dose-rate of 60 rads/min., was carried beyond 450 to 600 rads, the electrophoretic mobility was observed to decrease to a minimum at 900 rads, slightly lower than the value for the unirradiated controls. On further increase of the dose, the mobility increased to a new maximum at 1200 rads, equal to that obtained at 600 rads. Thereafter the mobility decreased again, reaching another minimum at about 1500 rads. The increase due to radiation was the same as that previously obtained with formaldehyde.

• Research Organization: Cambridge Univ., Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-008585
• OSTI ID: 4801146
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4812 Vol. 193; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMAL CELLS
ELECTROPHORESIS
FORMALDEHYDE
FORMIC ACID
GAMMA RADIATION
RADIATION DOSES
RADIATION EFFECTS
TUMORS
WATER
X RADIATION