LOCALIZATION OF GOLD IN MOUSE BRAIN IN RELATION TO GOLD THIOGLUCOSE OBESITY
Administration of gold thioglucose led to the development of hyperphagia and obesity in mice; this confirmed findings by previous investigators. By employing neutron activation analysis and radioautography, it was observed that this syndrome was associated with focal accumulation of gold in the hypothalamus. Animals treated with gold thiomalate failed to show any hypothalamic Iocalization of gold radioautographically or any evidence of the syndrome of hyperphagla and obesity. In additlon, other foci of gold locallzation were found in gold thioglucose-treated but not in the gold thiomalate-treated animals. Gamma spectroscopy studies made possible quantitative measurements of the gold content ln the brains of both treated groups. Gold thioglucose-treated as well as gold thiomalate-treated animals had appreciable quantities of gold in the brain proper. Phosphorus-32 generated by neutron activation of the sulfur moiety of gold thioglucose proved to be insigniflcant in its contribution to the radioautographic flndings. Implication of the above findings for the glucostatic theory of appetite regulation is discussed. (auth)
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- NSA Number:
- NSA-16-014396
- OSTI ID:
- 4798700
- Report Number(s):
- BNL-5783; 0002-9513
- Journal Information:
- American Journal of Physiology (U.S.), Vol. Vol: 202, Issue 4; Other Information: BNL-5783. Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- United States
- Language:
- English
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