THE EFFECT OF DOSE-RATE AND FRACTIONATION ON ACUTE MORTALITY IN X- IRRADIATED MICE. PART II

Journal Article · Wed Aug 01 04:00:00 EDT 1962 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006214550941· OSTI ID:4797699

Brown, J A.H.; Corp, M J; Mole, R H

Changing the exposure time from 15 min to less than 1 min and the dose- rate from 54 to 1100 rads/min did not reduce the LD/sub 50/30/ of mice by more than a few per cent. Changes in the uniformity of tissue dose, as by changing the direction of the x-ray beam, were quantitatively much more important. The effect of increasing exposure time from 6 to 36 hours with continuous irradiation was compared with other exposures spread over similar periods of time but divided into 2, 4, or 18 equal fractions, each at a relatively high dose-rate. Neither with continuous nor with fractionnted exposures did the LD/sub 50/30 increase indefinitely as overall exposure time was prolonged. The rapid phase of decay of radiation damage appeared to stop early, at 6 hours, after a single dose but not until after 18 hours of prolonged exposure,

• Research Organization: Medical Research Council, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-000080
• OSTI ID: 4797699
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 5
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
DECAY
LIFETIME
MICE
RADIATION DOSES
RADIATION EFFECTS
TISSUES
X RADIATION