THE MODIFICATION OF ACUTE MORTALITY IN MICE BY VARIATION OF THE DOSE-RATE AND THE OVERALL TIME OF IRRADIATION

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553005914550351· OSTI ID:4237957

Corp, M J; Neal, F E

A method is described whereby a 250 Kvcp x-ray set has been used to simulate whole-body irradiation by the fall-out from a nuclear weapon during the first 25 hours after its explosion when the dose-rate is continuously varying. LD/sub 50/30/ from such a fall-out exposure was 8% less than the LD/sub 50/30/ for a 25-hr exposure at a constant doserate. Both these values were more than 50% greater than the LD/sub 50/30/ for a short exposure lasting less than a quarter of an hour at a dose-rate about a hundred times greater. During the first 30 days after irradiation there was no qualitative difference between any of the groups in the times of death or in the manner of death. Hemorrhages were the commonest cause of death and were seen mostly in the brain and spinal cord. Deaths between 30 and 200 days were seen only in the high dose-rate group. They were due to a characteristic gastrointestinal distrubance. (auth)

• Research Organization: Atomic Energy Research Establishment, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-002293
• OSTI ID: 4237957
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
BRAIN
FALLOUT
HEMORRHAGE
INTESTINE
LETHAL DOSE
MICE
NERVOUS SYSTEM
NUCLEAR EXPLOSIONS
RADIATION DOSES
RADIATION SICKNESS
SPINAL CORD
X RADIATION